14.9%
Mean weight loss with semaglutide 2.4 mg
Over 68 weeks in the STEP-1 trial of 1,961 adults with overweight or obesity — vs. 2.4% with placebo.
STEP-1 · Wilding et al., NEJM 2021 ↗Spring Special — $179 first month + Free 1-2 Day Shipping · Cancel Anytime
Clinically-Studied GLP-1 Weight Loss*
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Up to 20.9% body weight loss in published GLP-1 trials*
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*Up to 20.9% average body weight loss over 72 weeks with tirzepatide 15mg in the SURMOUNT-1 trial (Jastreboff et al., N Engl J Med 2022); up to 14.9% over 68 weeks with semaglutide 2.4mg in the STEP-1 trial (Wilding et al., N Engl J Med 2021). Results are from studies of FDA-approved branded medications and may not reflect outcomes with compounded formulations. Individual results vary; weight loss is not guaranteed.
Research Published In
AvataCore treatment protocols are informed by clinical data from peer-reviewed research.
14.9%
Avg. body weight reduction with semaglutide 2.4mg at 68 weeks1
20.9%
Avg. body weight reduction with tirzepatide 15mg at 72 weeks2
86%
Of STEP 1 participants lost ≥5% of body weight1
24/7
Licensed provider support via our clinical partner
1 Wilding et al., N Engl J Med 2021 (STEP 1) · 2 Jastreboff et al., N Engl J Med 2022 (SURMOUNT-1)
Individual results vary. Trial data does not guarantee outcomes.
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GLP-1 Injections
One simple injection per week.
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Needle-free daily tablet — same active ingredient as Ozempic®
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GLP-1 Tablets
One dissolvable tablet per day.
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Tirzepatide Injections
Dual-agonist GLP-1 + GIP, weekly injection.
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Average body weight reduction reported in peer-reviewed GLP-1 trials
Tirzepatide 15 mg
SURMOUNT-1 · 72 weeks · Jastreboff et al., NEJM 2022
20.9%
Semaglutide 2.4 mg
STEP-1 · 68 weeks · Wilding et al., NEJM 2021
14.9%
Placebo + lifestyle
Control arm reference (STEP/SURMOUNT pooled)
~3%
86%
Of STEP-1 participants achieved ≥5% body weight loss
2,539
Adults randomized in SURMOUNT-1 trial
68-72 wk
Treatment duration in pivotal trials
Trial data reflects FDA-approved formulations of semaglutide and tirzepatide. Compounded formulations contain the same active ingredients; outcomes with compounded preparations may differ. Individual results vary based on dose, adherence, diet, and other factors. Weight loss is not guaranteed. References: Wilding JPH et al., NEJM 384:989-1002 (2021); Jastreboff AM et al., NEJM 387:205-216 (2022).
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From Peer-Reviewed Research
What the clinical data actually shows.
Six findings from the pivotal GLP-1 trials that define how we build our care plans. No cherry-picked quotes — just the numbers from the peer-reviewed record.
20.9%
Mean weight loss with tirzepatide 15 mg
Over 72 weeks in the SURMOUNT-1 trial of 2,539 adults — the highest reduction in any published GLP-1 study to date.
SURMOUNT-1 · Jastreboff et al., NEJM 2022 ↗86%
Achieved ≥5% body weight loss
Clinically meaningful weight reduction threshold reached by the vast majority of STEP-1 participants — the benchmark providers care about.
STEP-1 · Wilding et al., NEJM 2021 ↗6×
More weight loss than lifestyle alone
Pooled GLP-1 trial arms showed 6× the weight reduction of placebo + lifestyle modification groups over the same duration.
STEP / SURMOUNT pooled control arms ↗~70%
Of weight regulation is biological
Appetite, satiety, and metabolic set point are largely governed by hormones — not willpower. GLP-1 works with your biology, not against it.
Obesity is a chronic disease · AMA 2013 ↗72 wk
Duration needed to see maximum effect
Pivotal trials run 68–72 weeks. Weight loss continues throughout — which is why our care plans are built for the long arc, not 30 days.
STEP-1 · SURMOUNT-1 ↗Take the Quiz →
Trial data reflects FDA-approved formulations. Compounded preparations contain the same active ingredients; outcomes may differ. Individual results vary. Weight loss is not guaranteed.
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